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This file contains the result of manual analysis of 43 non-ribosomal clusters 
identifed at delta = 1900bp. The first line for each cluster contains the operon name, from
RegulonDB and the functional annotation, generally from primary paper linked
at RegulonDB. The computationally predicted opersons are enclosed in braces.
Statistical significance values are given for some clusters. 
#########################################################################################################################################

8:2 atpIBEFHAGDC [ATP synthase]
F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) (atpC)(COG0355) AND F0F1-type ATP synthase, beta subunit (atpD)(COG0055) AND F0F1-type ATP synthase, gamma subunit (atpG)(COG0224) AND F0F1-type ATP synthase, alpha subunit (atpA)(COG0056) AND F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) (atpH)(COG0712) AND F0F1-type ATP synthase, subunit b (atpF)(COG0711) AND F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+ATPase, subunit K (atpE)(COG0636) AND F0F1-type ATP synthase, subunit a (atpB)(COG0356)
	4e-17

7:2 fliFGHIJK, fliE [Flagellar biosynthesis]
Flagellar hook-basal body protein (fliE) (COG1677) AND Flagellar biosynthesis/type III secretory pathway lipoprotein (fliF) (COG1766) AND Flagellar motor switch protein (fliG) (COG1536) AND Flagellar biosynthesis/type III secretory pathway protein (fliH) (COG1317) AND Flagellar biosynthesis/type III secretory pathway ATPase (fliI)(COG1157) AND Flagellar biosynthesis chaperone (fliJ)(COG2882) AND Flagellar hook-length control protein (fliK)(COG3144)
	5e-15

6:1 menFD-yfbB-menBCE	[Menaquinone (vitamin K2) biosynthesis]
Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II (menE)(COG0318) AND O-succinylbenzoate synthase (menC)(COG1441) AND Dihydroxynaphthoic acid synthase (menB)(COG0447) AND Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) (yfbB)(COG0596) AND 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menD)(COG1165) AND Isochorismate synthase (menF)(COG1169)
	1.152e-10

6:2 rbsDACBK, rbsR [ABC-type ribose transport system]
ABC-type ribose transport system, auxiliary component (rbsD)(COG1869) AND ABC-type sugar transport system, ATPase component (rbsA)(COG1129) AND Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components (rbsC)(COG1172) AND ABC-type sugar transport system, periplasmic component (rbsB)(COG1879) AND Sugar kinases, ribokinase family (rbsK)(COG0524) AND Transcriptional regulators (rbsR)(COG1609)
	1.259712e-07

5:1 nikABCDER [ABC-type dipeptide/oligopeptide/nickel transport system]
ABC-type dipeptide transport system, periplasmic component (nikA)(COG0747) AND ABC-type dipeptide/oligopeptide/nickel transport systems, permease components (nikB)(COG0601) AND ABC-type dipeptide/oligopeptide/nickel transport systems, permease components (nikC)(COG1173) AND ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component (nikD)(COG0444) AND ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component (nikE)(COG1124)
	1.617e-06

5:2 hisGDCBHAFI [Histidine biosynthesis]
Imidazoleglycerol-phosphate dehydratase (hisB)(COG0131) AND Glutamine amidotransferase (hisH)(COG0118) AND Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (hisA)(COG0106) AND Imidazoleglycerol-phosphate synthase (hisF)(COG0107) AND Phosphoribosyl-ATP pyrophosphohydrolase (hisI)(COG0140)
	1.2e-10


4:1 bioA, bioBFCD [biotin biosynthesis]
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA)(COG0161) AND Biotin synthase and related enzymes (bioB)(COG0502) AND 7-keto-8-aminopelargonate synthetase and related enzymes (bioF)(COG0156) AND Dethiobiotin synthetase (bioD)(COG0132)
	9.6e-08

4:2 fepDGC,fepB[ferric enterobactin transport system]; ybdA [putative transport]
ABC-type cobalamin/Fe3+siderophores transport systems, ATPase components (fepC)(COG1120) AND ABC-type Fe3+siderophore transport system, permease component (fepGD)(COG0609) AND Permeases of the major facilitator superfamily (ybdA)(COG0477) AND ABC-type Fe3+hydroxamate transport system, periplasmic component (fepB)(COG0614)
	1.4e-04

4:3 
Transcriptional regulators (yfeT)(COG1737) AND Predicted sugar phosphate isomerase (yfeU)(COG2103) AND Phosphotransferase system IIB components (b2429)(COG1264) AND Beta-lactamase class C and other penicillin binding proteins (b2430)(COG1680)
// b2429 - putative PTS enzyme II; b2430 -  putative beta-lactamase
	8.64e-07

4:4 {murE_murF_mraY_murD_ftsW_murG_murC_ddlB} []
UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase (mraY)(COG0472) AND UDP-N-acetylmuramoylalanine-D-glutamate ligase (murD)(COG0771) AND Bacterial cell division membrane protein (ftsW)(COG0772) AND UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase (murG)(COG0707)
	9.6e-08

4:5 mreBCD-yhdE-cafA [shape-determining genes]
Nucleotide-binding protein implicated in inhibition of septum formation (yhdE)(COG0424) AND Cell shape-determining protein (mreD)(COG2891) AND Cell shape-determining protein (mreC)(COG1792) AND Actin-like ATPase involved in cell morphogenesis (mreB)(COG1077)
	4.8e-08

4:6 leuLABCD [leucine biosynthesis]
3-isopropylmalate dehydratase small subunit  (leuD)(COG0066) AND 3-isopropylmalate dehydratase large subunit (leuC)(COG0065) AND Isocitrate/isopropylmalate dehydrogenase (leuB)(COG0473) AND Isopropylmalate/homocitrate/citramalate synthases (leuA)(COG0119)
	9.6e-08

4:7 narZYWV [Nitrate reductases]
Nitrate reductase gamma subunit (narV)(COG2181) AND Nitrate reductase delta subunit (narW)(COG2180) AND Nitrate reductase beta subunit (narY)(COG1140) AND Anaerobic dehydrogenases, typically selenocysteine-containing (narZ)(COG0243)
	2.496e-06	

4:8 {hisP_hisM_hisQ_hisJ} [ABC-type amino acid transport system]
ABC-type polar amino acid transport system, ATPase component (hisP)(COG1126) AND ABC-type amino acid transport system, permease component (hisMQ)(COG0765) AND ABC-type amino acid transport/signal transduction systems, periplasmic component/domain (hisJ, argT)(COG0834) AND 3-polyprenyl-4-hydroxybenzoate decarboxylase (ubiX)(COG0163)
	1.296e-05

4:9 entCEBA [enterobactin biosynthesis]
Aryl carrier domain (entB)(COG3433) AND Peptide arylation enzymes (entE)(COG1021) AND Isochorismate synthase (entC)(COG1169) AND Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) (entA)(COG1028)
	7.68e-07

3:1 cyoABCDE 
Heme/copper-type cytochrome/quinol oxidases, subunit 1(COG0843-cyoB) AND Heme/copper-type cytochrome/quinol oxidase, subunit 3(COG1845-cyoC) AND Heme/copper-type cytochrome/quinol oxidase, subunit 4(COG3125-cyoD)

3:2 {gspC_gspD_gspE_hofF_hofG_hofH}
Type II secretory pathway, component PulF(COG1459-hofF) AND Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB(COG2804-yheG) AND Type II secretory pathway, pseudopilin PulG(COG2165-hofG)

3:3 fliLMNOPQR
Flagellar biosynthesis pathway, component FliP(COG1338-fliP) AND Flagellar biosynthesis pathway, component FliQ(COG1987-fliQ) AND Flagellar biosynthesis pathway, component FliR(COG1684-fliR)

3:4 {rstA-rstB}
Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)(COG1028-ydgB) AND Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain(COG0745-rstA) AND Signal transduction histidine kinase(COG0642-rstB)

3:5 def-fmt
N-formylmethionyl-tRNA deformylase(COG0242-def) AND Methionyl-tRNA formyltransferase(COG0223-fmt) AND tRNA and rRNA cytosine-C5-methylases(COG0144-sun)

3:6 {ynhA-b1680-ynhC-ynhD-ynhE}
Selenocysteine lyase(COG0520-b1680) AND ABC-type transport system involved in Fe-S cluster assembly, permease component(COG0719-ynhC) AND ABC-type transport system involved in Fe-S cluster assembly, ATPase component(COG0396-ynhD)


3:8 panBC, panD
Aspartate 1-decarboxylase(COG0853-panD) AND Panthothenate synthetase(COG0414-panC) AND Ketopantoate hydroxymethyltransferase(COG0413-panB)

3:9 prbB, {prpC-prpD-prpE}
PEP phosphonomutase and related enzymes(COG2513-prpB) AND Uncharacterized protein involved in propionate catabolism(COG2079-prpD) AND Citrate synthase(COG0372-prpC)

3:10 sdhCDAB-b0725-sucABCD
Succinate dehydrogenase/fumarate reductase, cytochrome b subunit(COG2009-sdhC) AND Succinate dehydrogenase/fumarate reductase, flavoprotein subunit(COG1053-sdhA) AND Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit(COG0479-sdhB)

3:11 {yaeC-yaeE-abc}
ABC-type metal ion transport system, periplasmic component/surface antigen(COG1464-yaeC) AND ABC-type metal ion transport system, permease component(COG2011-yaeE) AND ABC-type metal ion transport system, ATPase component(COG1135-abc)

3:12 rfbBDACX
dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes(COG1898-rfbC) AND dTDP-glucose pyrophosphorylase(COG1209-rfbA) AND dTDP-D-glucose 4,6-dehydratase(COG1088-rfbB)

3:13 {ykgE_ykgF}, ykfG
Fe-S oxidoreductase(COG0247-ykgE) AND Uncharacterized conserved protein containing a ferredoxin-like domain(COG1139-ykgF) AND Uncharacterized conserved protein(COG1556-ykgG)

3:14 araBAD
Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases(COG0235-araD) AND L-arabinose isomerase(COG2160-araA) AND Ribulose kinase(COG1069-araB)

3:15 {ycjM-b1310-ycjO-ycjP-ycjQ-b1314-ycjS-ycjT-ycjU-ycjV}
ABC-type sugar transport system, periplasmic component(COG1653-b1310) AND ABC-type sugar transport systems, permease components(COG1175-ycjO) AND ABC-type sugar transport system, permease component(COG0395-ycjP)

3:16 pstSCAB-phoU
ABC-type phosphate transport system, ATPase component(COG1117-pstB) AND ABC-type phosphate transport system, permease component(COG0581-pstA) AND ABC-type phosphate transport system, permease component(COG0573-pstC)

3:17 rpmH-rnpA
Preprotein translocase subunit YidC(COG0706-yidC) AND RNase P protein component(COG0594-rnpA) AND Ribosomal protein L34(COG0230-rpmH)

3:18 {proV_proW}, proX
ABC-type proline/glycine betaine transport systems, ATPase components(COG1125-proV) AND ABC-type proline/glycine betaine transport systems, permease component(COG1174-proW) AND ABC-type proline/glycine betaine transport systems, periplasmic components(COG2113-proX)

3:19 celABCDF-ydjC
Phosphotransferase system cellobiose-specific component IIA(COG1447-celC) AND Phosphotransferase system cellobiose-specific component IIC(COG1455-celB) AND Phosphotransferase system cellobiose-specific component IIB(COG1440-celA)

3:20 {queA-tgt-yajC-secD-secF}
S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)(COG0809-queA) AND Queuine/archaeosine tRNA-ribosyltransferase(COG0343-tgt) AND Preprotein translocase subunit YajC(COG1862-yajC)

3:21 {yabB_yabC_ftsL_ftsI}
Uncharacterized protein conserved in bacteria(COG2001-yabB) AND Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis(COG0275-yabC) AND Cell division protein FtsI/penicillin-binding protein 2(COG0768-ftsI)

3:22
ABC-type metal ion transport system, periplasmic component/surface adhesin(COG0803-yebL) AND ABC-type Mn/Zn transport systems, ATPase component(COG1121-yebM) AND ABC-type Mn2+/Zn2+ transport systems, permease components(COG1108-yebI)

3:23 trpCBA
Tryptophan synthase alpha chain (COG0159-trpA) AND Tryptophan synthase beta chain COG0133-trpB) AND Indole-3-glycerol phosphate synthase (COG0134-trpC)

3:24 tauABCD
ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components(COG0715- tauA) AND ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component(COG1116-tauB) AND ABC-type nitrate/sulfonate/bicarbonate transport system, permease component(COG0600- tauC)

3:25 {yehW_yehX_yehY_yehZ}
ABC-type proline/glycine betaine transport systems, permease component(COG1174-yehWY) AND ABC-type proline/glycine betaine transport systems, ATPase components(COG1125-yehX) AND Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)(COG1732-yehZ)

3:26 dnaAN-recF
Recombinational DNA repair ATPase (RecF pathway)(COG1195-recF) AND DNA polymerase sliding clamp subunit (PCNA homolog)(COG0592-dnaN) AND ATPase involved in DNA replication initiation(COG0593-dnaA)

3:27 fabDG-acpP
(acyl-carrier-protein) S-malonyltransferase(COG0331-fabD) AND Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)(COG1028-fabG) AND Acyl carrier protein(COG0236-acpP)

3:28 emrRAB
Transcriptional regulators(COG1846-emrR) AND Multidrug resistance efflux pump(COG1566-emrA) AND Permeases of the major facilitator superfamily(COG0477-emrB)

3:29 malEFG
ABC-type sugar transport system, permease component(COG0395-malG) AND ABC-type sugar transport systems, permease components(COG1175-malF) AND Maltose-binding periplasmic proteins/domains(COG2182-malE)